Brain Organoids: Human Neurodevelopment in a Dish
نویسندگان
چکیده
منابع مشابه
Cerebral Organoids in a Dish: Progress and Prospects
A three-dimensional culture of cortical tissues derived from pluripotent stem cells offers an opportunity to model human brain development and disorders. In a recent issue of Nature, Lancaster et al. describe a new method for generating cerebral organoids in a dish and use it to model microcephaly.
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Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased considerably in Brazil; however, causality between the viral epidemic and malformations in fetal brains needs further confirmation. We examined the effects of ZIKV infection in human neural stem cells growing as neurospheres and brain organoids. Using immunocytochemistry and electron microscopy, we showed that ZIKV...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2019
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a035709